Document 0611
 DOCN  M9480611
 TI    The association of human papillomavirus infection with balanoposthitis:
       a description of five cases with proposals for treatment.
 DT    9410
 AU    Birley HD; Luzzi GA; Walker MM; Ryait B; Taylor-Robinson D; Renton AM;
       Department of Genitourinary Medicine and Communicable Disease, St;
       Mary's Hospital Medical School, London, UK.
 SO    Int J STD AIDS. 1994 Mar-Apr;5(2):139-41. Unique Identifier : AIDSLINE
       MED/94305011
 AB    The features and clinical course of chronic balanitis in 5 patients are
       presented. In each case, histological examination of a cutaneous biopsy
       sample showed pronounced features of human papillomavirus (HPV)
       infection. In addition, HPV DNA was demonstrated in each biopsy specimen
       by a polymerase chain reaction and was found to be type 6 by Southern
       blot hybridization in 4 of the cases. Although the association of
       histological features of HPV infection with balanitis does not prove
       that HPV is causal, the failure to find other causes, the prolonged and
       distressing symptoms, and the ineffectiveness of topical steroids in
       improving symptoms, all suggest the importance of HPV infection. While
       effective treatment needs to be sought and developed, the response of
       one patient to oral isotretinoin suggests that this agent may be
       appropriate for a larger trial.
 DE    Administration, Oral  Administration, Topical  Adult
       Balanitis/*MICROBIOLOGY  Biopsy  Blotting, Southern  Case Report  DNA,
       Viral/*ANALYSIS  Human  Isotretinoin/THERAPEUTIC USE  Male
       *Papillomavirus, Human/CLASSIFICATION  *Papovaviridae Infections/DRUG
       THERAPY  Polymerase Chain Reaction  Serotyping  Steroids/THERAPEUTIC USE
       Treatment Outcome  *Tumor Virus Infections/DRUG THERAPY  JOURNAL ARTICLE

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